
Catalytic Impact Fund
Multiply your impact through catalytic giving
We target opportunities in Global Health & Development where small investments can generate extraordinary impact and create lasting change. Every contribution goes to the highest-leverage interventions, saving and improving as many lives as possible with each dollar.
By prioritizing these leverage points, we help donors maximize their impact in building sustainable, long-term solutions to global poverty and suffering.
What we do
Unlock transformational change
There are many charities that address global poverty and suffering. We try to find the strategic pressure points where modest funding unlocks transformational change.
We look for grants that multiply impact beyond the immediate effect of the funding itself. Rather than just funding programs that help people today, we prioritize opportunities that demonstrate how a small investment can generate sustained outsized returns.
What catalytic impact can look like:
- We trigger systemic improvements: We support investments that create new long-term infrastructure or increase the cost-effectiveness of existing systems.
- We remove key bottlenecks: We identify and remove barriers that stand in the way of accelerated impact.
- We crowd in capital: We provide early-stage funding that attracts substantial follow-on investment for cost-effective opportunities.
Our Impact
Our 2025 Catalytic Impact Fund Impact Report highlights how our GHD Program is responding to significant disruptions to global aid. In 2025, this newly relaunched Fund supported interventions where modest philanthropic capital unlocked outsized returns -- funding that triggered systemic improvements, removed critical bottlenecks, or crowded in follow-on investment.
Read the report to see how the catalytic lens applied to this fund works to fill a crucial gap in effective giving by supporting transformational opportunities. These grants are designed to multiply impact far beyond our initial investment, creating sustainable change in the global health and development ecosystem

Give to the Fund
Donate to the Catalytic Impact Fund to help drive lasting systemic change and unlock compounding impact for years to come.
Donate to the Catalytic Impact Fund
Catalytic Impact Fund: Impact Stories

▲ Photo from Lead Exposure Elimination Project

▲ Opening Extractives launch in Armenia, May 2022. Source: EITI

▲ With reading glasses, Rosa was able to continue work as a seamstress. Source: RestoringVision
Our grants
Within our GHD Program, we make grants to catalytic opportunities that multiply impact beyond immediate funding effects. Our rigorous evaluation process focuses on identifying interventions where modest investments can trigger systemic improvements, crowd in additional funding, or remove critical bottlenecks. Each grant is carefully assessed for its potential to generate outsized returns and create lasting change in global well-being. Here’s how we do it.
*Grants marked with an asterisk were not originally paid in USD; the amounts shown are converted reference values.
Africa's regulatory systems for approving medicines are slow, fragmented, and under-resourced, blocking access to life-saving treatments. Our funding supports 1DaySooner's technical assistance to the African Medicines Agency (AMA), a newly launched continental regulator. 1DaySooner aims to help AMA integrate AI tools to speed up regulatory document review and strengthen guidance for human challenge studies, which generate clinical trial evidence quickly and cheaply. This grant aims to shape the AMA's foundational systems at a critical moment.
Depression and anxiety affect an estimated 90 million people in India, yet 85% of those with depressive disorders receive no treatment due to cost, stigma, and a shortage of mental health professionals. Our funding supports Kaya Guides as they scale a WhatsApp-delivered guided program that reaches Indian youth experiencing depression at low cost based on promising results in other contexts.
Enabling the University of Chicago Development Innovation Lab (DIL) to hire weather forecasters and policy staff to create and disseminate forecasts that are more accurate and agriculturally relevant.
Advised grants
These grants have been identified, evaluated and advised on by Fund Managers; resources were deployed by external philanthropists through their giving infrastructure, separately from the Fund.
To scale up programs broadcasting locally-tailored educational content to children across Africa